The article Animal Models and Conserved processes was cited in http://www.annalsofintensivecare.com/content/4/1/26
These, and other similar findings, suggest that a systems biology approach to the nonlinear complex chaotic dynamics of mammalian organisms in which responses are extremely sensitive to initial conditions (the genome and its epigenetic regulatory mechanisms) explains the lack of translation. By this explanation, in principle, AR findings will not predict human responses.